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展开王祥瑞,男,主任医师,教授,1982年获医学学士学位,1990年获麻醉学硕士学位,1995年获药理学博士学位。中国医师学会麻醉分会常委,中华医学会疼痛分会全国委员,中华针灸学会针刺麻醉理事会副主任委员,中医药促进会软组织疼痛分会副主任委员,中华医学会麻醉学分会委员会委员,上海医学会麻醉学会副主任委员,上海医学会危重病学会委员,上海医学会疼痛专业委员会主任委员,上海针灸学会针刺麻醉分会副主任委员。论文著作1、 A preliminary study on the monitoring of mixed venous oxygen saturation through the left main bronchus. Critical Care 2006, 10:R7-R13Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha. Cell Res. 2006 Jun;16(6):548-583、Low hematocrit worsens cerebral injury after prolonged hypothermic circulatory arrest in rats. CAN J ANESTH 2006 , 53( 12 ): 1220–12294、Up-regulation of Hypoxia Inducible Factor 1alpha by Isoflurane in Hep3B Cells. Anesthesiology. 2006 Dec;105(6):1211-12195、Activations of mitogen-activated protein kinase and nuclear factor-kappaB by mechanical stretch result in ventilation-induced lung injury. 2007;68:356-360 Med Hypotheses.6、Response of Alveolar Type II Epithelial Cells to Mechanical Stretch and Lipopolysaccharide. 2007;74(5):579-85 Respiration7、Dose-dependent neuroprotection of delta opioid peptide [D-Ala2, D-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats. 2007;423(2):113-7 Neurosci Lett.8、Role of Rel A and IkappaB of nuclear factor kappaB in the release of interleukin-8 by cyclic mechanical strain in human alveolar type II epithelial cells A549. 2007 Nov;12(6):792-8 Respirology.9、Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats. 2008Jan 31;431(2):129-34. Neurosci Lett10、Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res.2009Oct 6;1292:100-106.11、In reply to ‘‘Is intrathecal lidocaine administration risk-free in rats with neuropathic pain?” Eur J Pain.2009, 13(6):89112、Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain.2009 Feb;13(2):130-13713、Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection. Cancer Sci.2010 Feb;101(2):412-41514、Resection of the nerves bundle from the sphenopalatine ganglia tend to increase the infarction volume following middle cerebral artery occlusion. Neurol Sci.2010 Aug;31(4):431-43515、Lidocaine attenuates proinflammatory cytokine production induced by extracellular adenosine triphosphate in cultured rat microglia. Anesth Analg. 2010 Sep;111(3):768-77416、Time course of action and pharmacokinetics of ropivacaine in adult and elderly patients following combined lumbar plexus-sciatic nerve block. Int J Clin Pharmacol Ther.2010 Sep;48(9):608-61317、Repeated but not single isoflurane exposure improved the spatial memory of young adult mice.. Acta Anaesthesiol Scand,2011;55(4):468-473.18、Delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia.. Eur J Pharmacol,2011;658(2-3):140-144.19、Hydroxyethyl Starch (130 kD) Inhibits Toll-Like Receptor 4 Signaling Pathways in Rat Lungs Challenged with Lipopolysaccharide.. Anesth Analg,2011;113(1):112-11920、Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil.. PLoS One.,2011;6(11):e27632.21、Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice.. World J Gastroenterol.,2011;17(48):5267-5273.22、Isoflurane Exposure during Mid-Adulthood Attenuates Age-Related Spatial Memory Impairment in APP/PS1 Transgenic Mice. PLoS One.,2012;7(11):e50172.23、Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.. J Surg Res.,2012;175(2):e61-66.24、Protective Effects of the Delta Opioid Peptide [D-Ala2, D-Leu5]enkephalin in an Ex Vivo Model of Ischemia/Reperfusion in Brain Slices.. CNS Neurosci Ther.,2012;18(9):762-766.25、Changes in pressure pain thresholds and Basal electromyographic activity after instrument-assisted spinal manipulative therapy in asymptomatic participants: a randomized, controlled trial.. J Manipulative Physiol Ther.,2012;35(6):437-445.26、Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system.. Anesthesiology.,2012;116(2):406-41427、Lipopolysaccharide Induces Lung Fibroblast Proliferation through Toll-Like Receptor 4 Signaling and the Phosphoinositide3-Kinase-Akt Pathway.. PLoS ONE,2012;7(4):e3592628、Isoflurane Prevents Neurocognitive Dysfunction After Cardiopulmonary Bypass in Rats.. J Cardiothorac Vasc Anesth.,2013 Jun;27(3):502-9.29、Epigenetic regulation of Thy-1 gene expression by histone modification is involved in lipopolysaccharide-induced lung fibroblast proliferation.J Cell Mol Med. 2013 Jan;17(1):160-7.30. TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury. Lab Invest, 2013 Jul;93(7):792-800.31. Toll-like receptor 4 mediates acute lung injury induced by high mobility group box-1. PLoS One, 2013 May 17;8(5):e64375.32. Smaller Sized Inhaled Anesthetics have More Potency on Senescence-Accelerated Prone-8 Mice Compared with Senescence-Resistant-1 Mice. J Alzheimers Dis, 2013 Oct.创新专利实用新型专利:支气管内环境微型无创压力温度监测装置气管插管牙齿保护套经气道无创监测混合静脉血氧饱和度气管导管支气管内环境微型无创pH值监测装置电针调控人体循环生物信息伺服装置针刺镇痛生物信息整合与反馈装置人体疼痛生物信息多参数整合即时评估装置呼吸道高压氧气喷射给药装置获得荣誉2006年,针麻心脏手术心肺保护作用及机制研究,获中国针灸学会(二等奖);2006年,复合针刺技术对围术期缺血心肌保护作用及其机制研究,获上海市医学奖(三等奖);2008年,手术病人循环功能调控新策略,获上海市科技进步奖(三等奖);2009年,低氧耐受及呼吸道压力生物学效应与术后肺部并发症;2009年,上海市育才奖
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